Nirogacestat binds to GS, blocking proteolytic activation of Notch receptors; Notch signaling pathway inhibition may follow, which may result in the induction of apoptosis in tumor cells that overexpress Notch. feeling tired. Nirogacestat was shown to be safe with manageable side effects; 95% of treatment-emergent adverse events were low grade. Once participants are eligible to roll into the open-label phase, they will receive nirogacestat. PF-03084014 does not show a paradoxical increase in plasma A at low concentrations in both preclinical species and humans. . - 2 of 2 defined stereocentres. This study evaluates nirogacestat (PF-03084014) in the treatment of desmoid tumor/aggressive fibromatosis (DT/AF). Nirogacestat is an investigational, oral, small molecule, selective gamma-secretase inhibitor. "Desmoid tumors are aggressive soft-tissue tumors that can lead to severe negative outcomes for patients, including long-lasting pain, disfigurement, and amputation. Its therapeutic effects currently are being investigated in heavily treated patients with multiple myeloma that has relapsed or failed to respond to treatment (refractory). These common side effects are much less . Nirogacestat: Type: Formula: C 27 H 41 F 2 N 5 O: Weight: Average: 489.656 Monoisotopic: 489.327917286 : Groups: Investigational: Therapeutic Class: Manufacturer: Available Country: Last Updated: August 5, 2021 at 12:40 pm: Structure Nirogacestat Structure. Nirogacestat enhances docetaxel-mediated tumor response and provides a rationale to explore GSIs as adjunct . Requests for access to a SpringWorks investigational therapy must be made voluntarily by the patient's treating physician. Requests cannot be made directly by an individual patient or a patient's parent/legal guardian or caregiver. No dose reductions occurred in the placebo arm, and only one discontinuation was reported. Molecular Formula CHFNO. At the time of submission, nirogacestat was not authorised anywhere in the EU for the treatment of soft tissue sarcoma. Once participants are eligible to roll into the open-label phase, they will receive nirogacestat.. Clinical Trials Registry. had your injection. Nirogacestat enhances the Antitumor Effect of Docetaxel in Prostate Cancer. Other typical side effects included fatigue, headache, muscle pain, chills, joint pain, diarrhea, fever and vomiting all were seen with Pfizer's original COVID-19 booster too. Nirogacestat | C27H41F2N5O | CID 46224413 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities . To request expanded access or compassionate use, physicians should send an email to medinfo@springworkstx.com. Nirogacestat enhances the Antitumor Effect of Docetaxel in Prostate Cancer. headache, aches and chills. Nirogacestat, a selective gamma-secretase inhibitor, has been investigated in 24 patients with desmoid tumors across Phase 1 and Phase 2 studies; the Company is planning a Phase 3 study (DeFi . Treatment with nirogacestat resulted in a 71% reduction in the risk of disease progression among adults with progressing desmoid tumors. Reduced ocular events, particularly Grade 3, 12.5% (2/10 in DE and 1/14 in CE) were observed in patients dosed with low dose belamaf + nirogacestat. Nirogacestat (PF-3084014) is a reversible, orally bioavailable, noncompetitive, and selective -secretase inhibitor with an IC50 of 6.2 nM. In the double-blind phase, half of the participants will receive nirogacestat while the other half will receive placebo. Nirogacestat may stop the growth of tumor cells by blocking some of the enzymes . Nirogacestat enhances the Antitumor Effect of Docetaxel in Prostate Cancer. The most common grade 3 or greater TEAEs in the nirogacestat and placebo arms, respectively, included diarrhea (16% vs 1%), maculopapular rash (6% vs 0%), stomatitis (4% vs 0%), fatigue (3% vs. Inhibition of Notch signaling by Nirogacestat while minimizing gastrointestinal toxicity presents a promising approach for research of Notch receptor-dependent cancers. Nirogacestat, also known as PF-03084014, is a potent and selective gamma secretase (GS) inhibitor with potential antitumor activity. Feelings and Cancer. Can be aggressive or slow-growing. 4 Nirogacestat elicited an ORR of 29.4%, with no progressive. diarrhoea, nausea and vomiting. In the double-blind phase, half of the participants will receive nirogacestat while the other half will receive placebo. Nirogacestat (gamma secretase inhibitor) Gamma secretase cleaves multiple transmembrane proteins, including Notch, that are believed to play a role in activating pathways that contribute to growth of desmoid and ovarian granulosa cell tumors. The analyst recapped the DeFi study results. Some people experience a little discomfort and can continue to go about their day. flushing as your body adjusts to this medication. "We believe the overall results present a strong case for nirogacestat becoming the standard of care systemic treatment in desmoid tumors," wrote Nierengarten. This phase II trial studies the side effects and how well nirogacestat works in treating patients patients less than 18 years of age with desmoid tumors that has grown after at least one form of treatment by mouth or in the vein that cannot be removed by surgery. This study is for patients over 1 year of age and under age 18. Heat can cause a syncope episode. SpringWorks is in the process of testing Nirogacestat as a monotherapy in patients with desmoid tumors. Nirogacestat exhibited a manageable safety profile in the DeFi trial, with 95% of all treatment-emergent adverse events (TEAEs) reported as Grade 1 or 2. 29 Sep 2022 SpringWorks Therapeutics plans to submit NDA for fibroma to the US FDA in the second half of 2022. However, whether it has the therapeutic effect on abnormal bone resorption remains to be evaluated. Description: Nirogacestat, also known as PF-03084014, is a potent and selective gamma secretase (GS) inhibitor with potential antitumor activity. By blocking gamma secretase, nirogacestat is expected to increase the amount of BCMA on the surface of cancer cells, and boost the effectiveness of BCMA-targeted therapies. Very common side effects in the first day or two include: having a painful, heavy feeling and tenderness in the arm where you had your injection. The ORR in belamaf + nirogacestat combination cohorts was 38% (9/24) and 17% achieved VGPR (4 . Nirogacestat may stop the growth of tumor cells by blocking some of the . 8019 Background: Preclinical data demonstrate that nirogacestat, a gamma-secretase inhibitor, may increase cell-surface levels of a B-cell maturation antigen (BCMA) and reduce soluble BCMA levels, which could enhance anti-BCMA agent activity in multiple myeloma. PF-03084014 is a highly potent -secretase inhibitor that reduces A production in vitro. Good examples are high-fiber cereals, beans, vegetables, and whole-grain breads. PF-03084014 binds to GS, blocking proteolytic activation of Notch receptors. diarrhoea, nausea and vomiting. Average mass 489.644 Da. We report four cases of pediatric and young adult desmoid tumor patients (three with familial adenomatous polyposis [FAP] syndrome) who received nirogacestat on compassionate use. This ongoing sub-study is actively recruiting patients and will continue to evaluate belamaf + nirogacestat efficacy and safety. This study evaluates nirogacestat (PF-03084014) in the treatment of desmoid tumor/aggressive fibromatosis (DT/AF). Nirogacestat may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Limit activity done outside on hot days. Disequilibrium of these two types of cells may undermine the soundness of bone structure, triggering a series of osteolytic diseases including osteoarthritis, osteoporosis and the aseptic peri-implant loosening [ [3], [4], [5] ]. Related Drugs 3-Phenylchromone Isoflavon Prexasertib Fevipiprant Axelopran Ozoralizumab This phase II trial studies the side effects and how well nirogacestat works in treating patients patients less than 18 years of age with desmoid tumors that has grown after at least one form of treatment by mouth or in the vein that cannot be removed by surgery. 1 Emerging clinical data also suggest that a GSI may increase antitumor efficacy of BCMA-targeted autologous CAR T therapy in patients with relapsed or refractory multiple myeloma. If these problems occur, they usually begin soon after vaccination and are mild and short-lived. Patients should recover from the serious side effects of previous therapies before receiving nirogacestat. as coadministration with nirogacestat may alter the plasma concentrations of oral contraceptives . Research. nirogacestat. [2] mild flu-like symptoms. Support for Caregivers. In the double-blind phase, half of the participants will receive nirogacestat while the other half will receive placebo. Summary. The median dose intensity was 288.3 mg/d (range, 169-300) with nirogacestat and 300.0 mg/d with placebo (range, 239-300). in preclinical models, nirogacestat has been shown to increase the cell surface density of bcma and reduce levels of soluble bcma, which may enhance the activity of bcma-targeted therapies. The most frequently reported TEAEs in participants receiving nirogacestat as compared to the placebo arm were diarrhea (84% vs 35%), nausea (54% vs 39%), and fatigue (51% vs 36%). Very common side effects in the first day or two may include: having a painful, heavy feeling and tenderness in the arm where you. Nirogacestat is an investigational, oral, selective, small molecule gamma-secretase inhibitor in Phase 3 clinical development for desmoid tumors, which are rare and often debilitating and disfiguring soft-tissue tumors. In agreement, preclinical data showed that myeloma cell death increased by 3,000 times when nirogacestat was added to GlaxoSmithKline 's Blenrep. Via this mechanism, nirogacestat may enhance the activity of BCMA-targeted therapies. This is being tested in a phase 3 study known as DeFi. By inhibiting gamma secretase, membrane-bound BCMA can be preserved, increasing target density while reducing levels of soluble BCMA ECD, which may serve as decoy receptors for BCMA-directed. Dose reductions were common in the nirogacestat arm at 42% (n = 29), but few patients required discontinuation (n = 14; 20%). This phase II trial studies the side effects and how well nirogacestat works in treating patients patients less than 18 years of age with desmoid tumors that has grown after at least one form of treatment by mouth or in the vein that cannot be removed by surgery. Appetite loss Frequent or recurrent infections Unintended weight loss Bone pain which may be worse in the spine or chest Nausea Fatigue Bone fractures Weakness or numbness in the legs Excessive thirst and frequent urination Constipation Mental confusion Hypercalcemia (excess calcium levels) What are your thoughts on being a rare disease advocate? Be careful in hot weather. At the time of submission of the application for orphan designation, clinical trials with nirogacestat in patients with soft tissue sarcoma were ongoing. Nirogacestat, also known as PF-03084014, is a potent and selective gamma secretase (GS) inhibitor with potential antitumor activity. "In terms of efficacy, we view nirogacestat as numerically better than both sorafenib and AL102," Nierengarten wrote. Nirogacestat may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Encouraging clinical activity and a manageable safety profile is observed with low dose belamaf (0.95 mg/kg Q3W) + nirogacestat (100 mg twice daily, continuously) in patients with RRMM. - Mechanism of Action & Protocol. Eat foods high in fiber to make it easier to have a bowel movement. Nirogacestat is an oral, small molecule that works by blocking gamma secretase , an enzyme that cleaves and detaches BCMA from the surface of myeloma cells. Nirogacestat has received Orphan Drug Designation from the U.S. Food and Drug Administration (FDA) for the treatment of desmoid tumors and from the European Commission for the treatment of soft . Locations Side Effects of Cancer Treatment. It is easy to find the trends and top topics of nirogacestat side effects here. Gamma secretase is an integral membrane protein that cleaves multiple different transmembrane protein . 2,3 Monoisotopic mass 489.327911 Da. headache, aches and chills. Belantamab mafodotin (GSK2857916); is an antibody-drug conjugate (ADC) containing humanized anti-BCMA monoclonal antibody (mAb). Prune juice may help make bowel movements softer. This is a randomized double-blind . SpringWorks Therapeutics Highlights Nirogacestat Clinical Data at the 2022 ASCO Annual Meeting. When compared to potential competing drugs sorafenib and AL102, nirogacestat is the best, Nierengarten noted. B-cell maturation antigen (BCMA) is a target present on tumor cells in participants with multiple myeloma. PF-03084014 in combination with dexamethasone elicits antileukemic effects in T-cell acute lymphoblastic leukemias (T-ALL). Nirogacestat is a selective gamma secretase (GS) inhibitor with potential antitumor activity. The gamma-secretase inhibitor nirogacestat has shown promising efficacy in adults. Median progression-free survival (PFS), in nirogacestat arm and placebo arm, were found to be, not estimable and 15.1 months, respectively at a median follow-up of 19.2 months (HR, 0.29; P < 0.001) Patient-reported outcomes ( PROs ), nirogacestat led to a significant reduction in pain severity at cycle 10 of treatment compared with placebo (P<0 . It was granted FDA breakthrough drug designation in September 2019 for adult patients with progressive, unresectable, recurrent or refractory desmoid tumors or deep fibromatosis. In the DREAMM-5 (NCT04126200) Phase I/II platform trial belantamab mafodotin (belamaf; BLENREP), a BCMA-targeting antibody-drug . Nirogacestat has received Orphan Drug Designation from the U.S. Food and Drug Administration (FDA) for the treatment of desmoid tumors and from the European Commission for the treatment of soft . This is a phase I/II, randomized, open-label, platform study designed to evaluate the effects of belantamab mafodotin in combination with other anti-cancer . Others have side effects that affect their ability to do daily activities. Side effects generally go away in a few days. Tell your doctor if you experience unlikely but serious side effects of Nitrostat including: Side effects of the coronavirus (COVID-19) vaccination. Again, the median PFS had not yet been reached at the time of the publication data because of a lack of tumor progression events. Conclusions -nirogacestat gamma secretase inhibitor Exciting potential for use in desmoid patients 72% RECIST response rate Active at even low doses (as low as 80mg BID) Tolerable side effect profile (primarily diarrhea, hypophosphatemia) Clinical benefit in 100% of patients (only patient with progression had PF-03084014 binds to GS, blocking proteolytic activation of Notch receptors. Complementary & Alternative Medicine (CAM) Questions to Ask about Your Treatment. PF-03084014 binds to GS, blocking proteolytic activation of Notch receptors. Results The gamma-secretase inhibitor nirogacestat has shown promising efficacy in adults. fever (temperature 37.8C or above) feeling generally unwell. Mary Smith, PhD, senior vice president of clinical research and development at SpringWorks Therapeutics explains the how nirogacestat works to treat individu. Bloating or swelling of the face, arms, hands, lower legs, or feet burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings difficult or labored breathing feeling faint, dizzy, or lightheadedness feeling of warmth or heat flushing or redness of the skin, especially on the face and neck headache rapid weight gain Nirogacestat is being investigated for the treatment of desmoid tumors due to its ability to bind to GS, blocking proteolytic activation of Notch receptors. Nirogacestat (PF-03084014) is a potent, small molecule, selective, reversible, noncompetitive inhibitor of -secretase (GS) with a potential antitumor activity. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. feeling tired. Adjusting to Cancer. Echemi supplies various nirogacestat side effects news. This phase II trial studies the side effects and how well nirogacestat works in treating patients patients less than 18 years of age with desmoid tumors that has grown after at least one form of treatment by mouth or in the vein that cannot be removed by surgery. Nirogacestat ( PF-03084014) is a selective gamma secretase inhibitor [1] developed by SpringWorks Therapeutics that has potential anti-tumor activity. Type Small Molecule Groups Investigational Structure 3D Download Similar Structures Weight Average: 489.656 This cohort within the DREAMM-5 nirogacestat combination sub-study has a sequential dose-exploration (DE) phase evaluating 0.95 mg/kg Q3W belamaf with 100 mg BID nirogacestat continuously, followed by a randomized cohort expansion (CE) comparing the combination to a belamaf 2.5 mg/kg Q3W arm. Nirogacestat DrugBank Accession Number DB12005 Background Nirogacestat has been used in trials studying the treatment of Breast Cancer, HIV Infection, Desmoid Tumors, Advanced Solid Tumors, and Aggressive Fibromatosis, among others. We report four cases of pediatric and young adult desmoid tumor patients (three with familial adenomatous polyposis [FAP] syndrome) who received nirogacestat on compassionate use. Self-Image & Sexuality. Published: May 26, 2022, 9:15 PM UTC GlobeNewswire - Initial Data to be Presented from GSK-Sponsored Phase 1/2 Study Evaluating Nirogacestat in Combination with Low-Dose BLENREP in Patients with Relapsed or Refractory Multiple Myeloma - Pain at the injection site was also the most common complaint among people boosted with Pfizer's updated vaccine; about 60 percent of trial participants reported it. This phase II trial studies the side effects and how well nirogacestat works in treating patients with desmoid tumors that has grown after at least one form of treatment by mouth or in the vein that cannot be removed by surgery. mild flu-like symptoms. 1 in. The primary endpoint, improvement in progression-free survival compared to placebo (p<0.001), was achieved, with patients in all . Side effects after getting a COVID-19 vaccine can vary from person to person. Nirogacestat is an investigational, oral, selective, small molecule gamma-secretase inhibitor in Phase 3 clinical development for desmoid tumors, which are rare and often debilitating and. A to Z List of Cancer Drugs. Clinical Trials Information. 29 Sep 2022 First patient dosed in a phase-II clinical trial in Ovarian cancer (Recurrent, Second-line therapy or greater) in USA (PO) (NCT05348356) 18 Sep 2022 Efficacy and adverse events data from a phase III DeFi trial in Fibroma . flushing (warmth, redness, or tingly feeling under your skin). Purpose. dizziness, lightheadedness, nausea, and. This study evaluates nirogacestat (PF-03084014) in the treatment of desmoid tumor/aggressive fibromatosis (DT/AF). A new drug application for nirogacestat is expected to be submitted to the FDA in the second half of 2022. Coping with Cancer. The effects of nirogacestat have been evaluated in experimental models. ChemSpider ID 26232306. Day-to-Day Life. Nirogacestat (PF-03084014, PF), a novel gamma-secretase inhibitor, has been used in phase II clinical trial for treatment of desmoid tumor. For more information about this study and to inquire about eligibility, please contact 1- 833-MSK-KIDS . nirogacestat (100 mg BID continuously) combination in patients with heavily pretreated RRMM. An online community for patients and their families Nirogacestat DeFi Trial Side Effects This conversation is about NCT03785964 Nirogacestat for Adults With Desmoid Tumor/Aggressive Fibromatosis (DT/AF) [phase 3] desmoid tumor Non-metastasizing tumors that can develop almost anywhere in the body. As with any medicine, there is a very remote chance of a vaccine causing a severe allergic reaction, other serious injury, or death. Once participants are eligible to roll into the open-label phase, they will receive nirogacestat. Other side effects of Nitrostat include: mild burning or tingling with the tablet in your mouth, and. 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